Pharmaceutical mopping systems need to effectively remove both non-viable and viable contamination, be capable of applying a disinfectant or detergent, dislodging biofilms, removing residues, suitable for autoclaving or sterilization, ergonomically friendly, easy to use, and not contribute to the overall bioburden or generate additional particulates. They also need to be compatible with a wide range of disinfectants including sporicides which are potentially aggressive chemicals.